| Round | Date | Result | ||
|---|---|---|---|---|
| Round 1 | 05/08/2000 | Beroe Stara Zagora | 0:2 | Levski Sofia |
| Round 2 | 13/08/2000 | Litex Lovech | 3:4 | Levski Sofia |
| Round 3 | 19/08/2000 | Levski Sofia | 2:1 | Slavia 1913 Sofia |
| Round 4 | 26/08/2000 | Chernomorets Burgas | 1:1 | Levski Sofia |
| Round 5 | 09/09/2000 | Levski Sofia | 4:1 | Hebar Pazardzhik |
| Round 6 | 16/09/2000 | Spartak 1918 Varna | 0:1 | Levski Sofia |
| Round 7 | 30/09/2000 | Levski Sofia | 4:0 | Minyor Pernik |
| Round 8 | 15/10/2000 | CSKA Sofia | 1:1 | Levski Sofia |
| Round 9 | 20/10/2000 | Levski Sofia | 1:0 | Lokomotiv Sofia |
| Round 10 | 28/10/2000 | Neftochimic 1962 Burgas | 0:1 | Levski Sofia |
| Round 11 | 11/11/2000 | Levski Sofia | 3:0 | Botev Plovdiv |
| Round 12 | 18/11/2000 | Cherno More Varna | 0:3 | Levski Sofia |
| Round 13 | 26/11/2000 | Levski Sofia | 2:0 | Velbazhd Kyustendil |
| Round 14 | 04/03/2001 | Levski Sofia | 3:0 | Beroe Stara Zagora |
| Round 15 | 10/03/2001 | Levski Sofia | 2:1 | Litex Lovech |
| Round 16 | 14/03/2001 | Slavia 1913 Sofia | 0:0 | Levski Sofia |
| Round 17 | 17/03/2001 | Levski Sofia | 4:0 | Chernomorets Burgas |
| Round 18 | 31/03/2001 | Hebar Pazardzhik | 0:1 | Levski Sofia |
| Round 19 | 07/04/2001 | Levski Sofia | 2:1 | Spartak 1918 Varna |
| Round 20 | 14/04/2001 | Minyor Pernik | 0:4 | Levski Sofia |
| Round 21 | 22/04/2001 | Levski Sofia | 2:1 | CSKA Sofia |
| Round 22 | 28/04/2001 | Lokomotiv Sofia | 0:2 | Levski Sofia |
| Round 23 | 06/05/2001 | Levski Sofia | 3:0 | Neftochimic 1962 Burgas |
| Round 24 | 11/05/2001 | Botev Plovdiv | 1:4 | Levski Sofia |
| Round 25 | 19/05/2001 | Levski Sofia | 6:0 | Cherno More Varna |
| Round 26 | 27/05/2001 | Velbazhd Kyustendil | 2:1 | Levski Sofia |
Note:
Срещата Миньор (Перник) - Левски (София) е прекратена при резултат 0:1, поради безредици по трибуните на стадиона в Перник и е присъден служебен резултат 4:0 в полза на гостите.